Mouse Models

Mouse Models, AAALAC

Applied StemCell is a leading CRISPR service company, and we have engineered hundred of mouse models for academic and corporate researchers successfully. Our animal model portfolio includes constitute and conditional knockout, site-specific knock-in, large fragment knock-in, gene overexpression and gene correction, to name a few.

  • Leading CRISPR service company. Find our name in Nature Biotechnology (2016) 34: 893-894. 
  • CRISPR technology licensed from the Broad Institute.
  • Applied StemCell's animal facility (California) has earned accreditation from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International). We ship animals internationally.
  • Please feel free to talk with us - we are happy to discuss your projects in detail and provide you with suitable strategic options to fit your budget and research needs.
CRISPR/Cas9 is a powerful new tool we use to generate mouse or rat models with point mutation(s), small reporter gene insertions, conditional or regular knockout(s). For knock-in large DNA fragments in mice, our proprietary site-specific knock-in technology TARGATT™ has a unique advantage and higher insertion efficiency over CRISPR.

Comprehensive Technology Platform for Gene Editing

Methods

Technical Advantage

TARGATT™ phiC31 integrase

  • Site specific integration (H11 or ROSA26)
  • Works for large DNA Knock-in (-22kb)

CRISPR / Cas9

  • High specificity
  • High frequency in Knockout, Conditional Knockout
  • Ease of use
  • Works for large DNA knock-in (-10kb)

 

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