IL6 & IL6R

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Strain Information

  • Catalog Number ASHU-190025
  • Model Name IL6 & IL6R
  • Strain Name C57BL/6 - Il6tm1(hIL6)Il6raem1(hIL6R)/Asc
  • GENE Synonyms Il, Il-6; Il6r, CD126, IL-6R, IL-6RA, IL-6R-alpha
  • Human Orthologs IL6; IL-6R
  • Emsamble ID ENSMUSG00000025746; ENSMUSG00000027947
  • MGI ID 96559; 105304
  • NCBI ID 16193; 16194
  • Background C57BL/6
  • Coat Color Black
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ASHU-190025
Catalog # :
ASHU-190025
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Validation Data

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Figure 1. The expression of human IL6 in liver tissue of humanized IL6/IL6R mice was measured by qPCR. The results showed that the active expression of humanized IL6 can be detected in liver tissue of homozygous humanized IL6/IL6R mice after LPS Activation. 

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Figure 2. Expression of human IL6 in the serum of humanized IL6/IL6R homozygous mice is detected by Elisa. The results showed that the expression of human IL6 can be detected in the serum collected from homozygous mice after LPS Activation. 

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Figure 3. Expression of human IL6R in the serum, liver and pancreas of humanized IL6/IL6R homozygous mice is detected by Elisa. The results showed that the expression of human IL6R can be detected in the serum, liver and pancreas collected from homozygous mice. 

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Figure 4. Detection of hIL-6R expression in MM.1S cells.

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Figure 5. Detection of hIL-6R expression in T cells in hIL-6/hIL-6R dKI mice.

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Figure 6. Detection of hIL-6R expression in Myeloid cells, T cells and activated B cells in hIL-6/hIL-6R dKI mice. Note: Splenocytes from C57BL/6 and homozygous IL-6/hIL-6R mice were stimulated with LPS in vitro

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Figure 7. Detection of hIL-6R expression in brainstem in hIL-6/hIL-6R dKI mice by IHC.

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Figure 8. Detection of hIL-6R expression in spleen in hIL-6 /hIL-6R dKI mice by IHC.

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Figure 9. Detection of hIL-6R expression in lung and thymus in hIL-6 /hIL-6R dKI mice by IHC.

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