IL6 & IL6R

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Strain Information

  • Catalog Number ASHU-190025
  • Model Name IL6 & IL6R
  • Strain Name C57BL/6 - Il6tm1(hIL6)Il6raem1(hIL6R)/Asc
  • Mutation Type Humanized
  • GENE Synonyms Il-6, CD126, IL-6R
  • Human Orthologs IL6, IL-6R
  • Emsamble ID ENSMUSG00000025746, ENSMUSG00000027947
  • MGI ID 96559, 105304
  • NCBI ID 16193, 16194
  • Background C57BL/6
  • Coat Color Black
  • Mutation Type Humanized
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ASHU-190025
Catalog # :
ASHU-190025
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Mouse
  • Description
  • Research Application
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Description

IL6 Humanized Strategy

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IL6R Humanized Strategy

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Validation Data

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Figure 1. The expression of human IL6 in liver tissue of humanized IL6/IL6R mice was measured by qPCR. The results showed that the active expression of humanized IL6 can be detected in liver tissue of homozygous humanized IL6/IL6R mice after LPS Activation. 

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Figure 2. Expression of human IL6 in the serum of humanized IL6/IL6R homozygous mice is detected by Elisa. The results showed that the expression of human IL6 can be detected in the serum collected from homozygous mice after LPS Activation. 

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Figure 3. Expression of human IL6R in the serum, liver and pancreas of humanized IL6/IL6R homozygous mice is detected by Elisa. The results showed that the expression of human IL6R can be detected in the serum, liver and pancreas collected from homozygous mice. 

Research Application
Immunotherapy
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