PD-1 & GITR - Immune Checkpoint Mouse Models - Mouse Repository - Animal Models - Research

SKU :
ASHU-190014
Catalog # :
ASHU-190014
Availability :
Mouse
The Programmed Cell Death Protein 1 (PDCD1) and the Glucocorticoid-induced TNFR-related protein (GITR) are inhibitory and co-stimulatory immune checkpoint proteins (respectively) that are key targets for current and developing cancer immunotherapies This double humanized PD-1 and GITR mouse model was established by crossing the PD-1-HU and GITR-HU mice. This double knock-in mouse model is ideal for evaluating the efficacy of potential combination immunotherapy drugs.
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Strain Information
  • Catalog Number ASHU-190014
  • Model Name PD-1 & GITR
  • Strain Name C57BL/6J - Pdcd1em1(hPDCD1) Tnfrsf18em1(hTNFRSF18)/Asc
  • Mutation Type Humanized
  • GENE Synonyms Ly101; AITR, Gitr
  • Human Orthologs PDCD1; TNFRSF18
  • Emsamble ID ENSMUSG00000026285; ENSMUSG00000041954
  • MGI ID 104879; 894675
  • NCBI ID 18566; 21936
  • Backgound C57BL/6J
  • Coat Color Black
  • Mutation Type Humanized
Description

The Programmed Cell Death Protein 1 (PDCD1) and the Glucocorticoid-induced TNFR-related protein (GITR) are inhibitory and co-stimulatory immune checkpoint proteins (respectively) that are key targets for current and developing cancer immunotherapies

This double humanized PD-1 and GITR mouse model was established by crossing the PD-1-HU and GITR-HU mice. This double knock-in mouse model is ideal for evaluating the efficacy of potential combination immunotherapy drugs.

Research Application
Immunotherapy
Availability
Mouse
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