IL6 & IL6R - Immune Checkpoint Mouse Models - Mouse Repository - Animal Models - Research

SKU :
ASHU-190025
Catalog # :
ASHU-190025
Availability :
Mouse
IL6 Humanized Strategy IL6R Humanized Strategy Humanized IL6/IL6R Mice Responded to LPS Stimulation and Robustly Expressed Human IL6 Validation of human IL6 mRNA and protein expression by Realtime-PCR and ELISA Mice were divided into two groups. One group was intraperitoneally injected with LPS at 3 mg/kg body weight, and the other group was injected with normal saline. After 4 h stimulation, the livers were harvested to extract RNA and the serum were used to detect protein expression .....
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Strain Information
  • Catalog Number ASHU-190025
  • Model Name IL6 & IL6R
  • Strain Name C57BL/6 - Il6tm1(hIL6) Il6raem1(hIL6R)/Asc
  • Mutation Type Humanized
  • GENE Synonyms Il-6; CD126, IL-6R
  • Human Orthologs IL6; IL-6R
  • Emsamble ID ENSMUSG00000025746; ENSMUSG00000027947
  • MGI ID 96559; 105304
  • NCBI ID 16193; 16194
  • Backgound C57BL/6J
  • Coat Color Black
  • Mutation Type Humanized
Description

IL6 Humanized Strategy

Landingpage-ASHU-190025-IL6&IL6R-HU-ICPMouse-1

IL6R Humanized Strategy

Landingpage-ASHU-190025-IL6&IL6R-HU-ICPMouse-2

Humanized IL6/IL6R Mice Responded to LPS Stimulation and Robustly Expressed Human IL6

Landingpage-ASHU-190025-IL6&IL6R-HU-ICPMouse-3

Validation of human IL6 mRNA and protein expression by Realtime-PCR and ELISA

Mice were divided into two groups. One group was intraperitoneally injected with LPS at 3 mg/kg body weight, and the other group was injected with normal saline. After 4 h stimulation, the livers were harvested to extract RNA and the serum were used to detect protein expression. (HO: humanized IL6 homozygous mice; WT: wild type C57BL/6 mice)

Validation of Human IL6R Protein Expression by ELISA

Landingpage-ASHU-190025-IL6&IL6R-HU-ICPMouse-4

Research Application
Immunotherapy
Availability
Mouse
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