IL17A & IL17F

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Strain Information

  • Catalog Number ASHU-200281
  • Model Name IL17A & IL17F
  • Strain Name C57BL/6-Il17aem2(hIL17A)Il17fem2(hIL17F)/Asc
  • Mutation Type Humanized
  • GENE Synonyms Ctla8, Ctla-8, Il17, IL-17A
  • Human Orthologs IL17A, IL17F
  • Emsamble ID ENSMUSG00000025929, ENSMUSG00000041872
  • MGI ID 107364, 2676631
  • NCBI ID 16171, 257630
  • Background C57BL/6
  • Coat Color Black
  • Mutation Type Humanized
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ASHU-200281
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ASHU-200281
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Validation Data

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Figure1. Analysis of IL17F gene expression in the kidney by RT-PCR.

Mouse Il17f mRNA was detectable by P1/2(440bp), human IL17F mRNA was detectable by P3/4(259bp).

M: 100bp Plus DNA ladder from Transgen (BM311). The heterozygous KI mice express both human IL17F and mouse Il17f in the kidney.

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Figure 2. Analysis of IL17A gene expression in the spleen by RT-PCR in WT and IL17A/IL17F humanized mice.

Mouse Il17a mRNA was detectable by P1/2 (490bp), human IL17A mRNA was detectable by P3/4(443bp).

M: 100bp Plus DNA ladder from Transgen (BM311). The heterozygous KI mouse expresses both human IL17A and mouse Il17a in the spleen.

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Figure 3. Detection of hIL17A expression in serum, spleen and thymus homogenate by ELISA (n=3). 

Abbr. HO, homozygous; WT, wild type. Note. hIL17A/hIL17F and C57BL/6 mice were i.p. injected with LPS.

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Figure 4. Detection of hIL17F expression in serum, spleen and thymus homogenate by ELISA (n=3). 

Abbr. HO, homozygous; WT, wild type. Note. hIL17A/hIL17F and C57BL/6 mice were i.p. injected with LPS.

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