IL17A & IL17F

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Strain Information

  • Catalog Number ASHU-200281
  • Model Name IL17A & IL17F
  • Strain Name C57BL/6-Il17aem2(hIL17A)Il17fem2(hIL17F)/Asc
  • Mutation Type Humanized
  • GENE Synonyms Ctla8, Ctla-8, Il17, IL-17A
  • Human Orthologs IL17A, IL17F
  • Emsamble ID ENSMUSG00000025929, ENSMUSG00000041872
  • MGI ID 107364, 2676631
  • NCBI ID 16171, 257630
  • Background C57BL/6
  • Coat Color Black
  • Mutation Type Humanized
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Validation Data


Figure1. Analysis of IL17F gene expression in the kidney by RT-PCR.

Mouse Il17f mRNA was detectable by P1/2(440bp), human IL17F mRNA was detectable by P3/4(259bp).

M: 100bp Plus DNA ladder from Transgen (BM311). The heterozygous KI mice express both human IL17F and mouse Il17f in the kidney.


Figure 2. Analysis of IL17A gene expression in the spleen by RT-PCR in WT and IL17A/IL17F humanized mice.

Mouse Il17a mRNA was detectable by P1/2 (490bp), human IL17A mRNA was detectable by P3/4(443bp).

M: 100bp Plus DNA ladder from Transgen (BM311). The heterozygous KI mouse expresses both human IL17A and mouse Il17a in the spleen.

Immunotherapy, drug screening