CTLA4

SKU :
ASHU-190078
Catalog # :
ASHU-190078
Availability :
Mouse
Validation Data   Figure 1. Expression of CTLA4 in the activated spleen lymphocytes of homozygous humanized CTLA4 BALB/c KI mice is detected by FACS. Figure 2. In vivo validation of homozygous BALB/c-hCTLA4 mice. The homozygous BALB/c-hCTLA4 mice were inoculated with CT26 cells, and randomly assigned to different groups (n=7) when the tumor grew to a volume of 100 mm3. A combinatorial treatment of anti-hCTLA4 antibody Yervoy  and entinostat (ENT; a class I HDAC inhibitor) demonstrated .....
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Strain Information
  • Catalog Number ASHU-190078
  • Model Name CTLA4
  • Strain Name BALB/c-Ctla4em1(hCTLA4) Asc
  • Mutation Type Humanized
  • GENE Synonyms Cd152, Ly-56, Ctla-4
  • Human Orthologs CTLA4
  • Emsamble ID ENSMUSG00000026011
  • MGI ID 88556
  • NCBI ID 12477
  • Backgound BALB/c
  • Coat Color White
  • Mutation Type Humanized
Description

Validation Data

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Figure 1. Expression of CTLA4 in the activated spleen lymphocytes of homozygous humanized CTLA4 BALB/c KI mice is detected by FACS.

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Figure 2. In vivo validation of homozygous BALB/c-hCTLA4 mice. The homozygous BALB/c-hCTLA4 mice were inoculated with CT26 cells, and randomly assigned to different groups (n=7) when the tumor grew to a volume of 100 mm3. A combinatorial treatment of anti-hCTLA4 antibody Yervoy  and entinostat (ENT; a class I HDAC inhibitor) demonstrated a noticeable efficacy improvement compared to the same dose of single agent (A) without affecting the animal body weight (B).

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Figure 3. In vivo validation of homozygous BALB/c-hCTLA4 mice. The homozygous BALB/c-hCTLA4 mice were inoculated with H22 cells, and randomly assigned to different groups (n=7) when the tumor grew to a volume of 100 mm3. Treatment of anti-hCTLA4 antibody Yervoy and Teremelimumab can effectively control tumor growth in BALB/c-hCTLA4 mice (A) without affecting the animal body weight (B).

Research Application
Immunotherapy, cancer research, drug screening
Availability
Mouse
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