PD-L1 & LAG3

Reference the resources below for more information about the product/service or contact us today to learn more.

Strain Information

  • Catalog Number ASHU-00137
  • Model Name PD-L1 & LAG3
  • Strain Name C57BL/6J - Cd274em1(hPD - L1)Lag3tm1(hLAG3)/Asc
  • Mutation Type Humanized
  • GENE Synonyms B7h1, Pdl1, Pdcd1l1, Pdcd1lg1, A530045L16Rik, Ly66, CD223, LAG-3
  • Human Orthologs CD274, LAG3
  • Emsamble ID ENSMUSG00000016496, ENSMUSG00000030124
  • MGI ID 1926446, 106588
  • NCBI ID 60533, 16768
  • Background C57BL/6
  • Coat Color Black
  • Mutation Type Humanized
Animal Request Form Inquire
Catalog # :
Availability :
  • Description
  • Research Application
  • Related Products

Humanized Strategy

Strategy for Generating Humanized PD-L1 (ASHU-00062) Mouse Model

landingpage-ashu-00137-PD-L1 & LAG3-hu-icpmouse-1

Strategy for Generating Humanized LAG3 (ASHU-00049) Mouse Model

landingpage-ashu-00137-PD-L1 & LAG3-hu-icpmouse-2

Validation Data

landingpage-ashu-00137-PD-L1 & LAG3-hu-icpmouse-3

Figure 1. Splenocytes from homozygous hPDL1/hLAG3 mice were analyzed by flow cytometry after activation. The mPDL1+ and mLAG3+ cells were detectable in wild type (WT) C57BL/6 mice, while the hPDL1+ and hLAG3+ cells were detectable in the homozygous hPD1/hLAG3 mice.

Immunotherapy, cancer research, drug screening