PD-L1 (2)

SKU :
ASHU-190039
Catalog # :
ASHU-190039
Availability :
Mouse
Validation Data   Figure 1. The expression of human PD-L1 in the peripheral blood cells derived from homozygous humanized mice were confirmed by flow cytometry analysis.  Figure 2.  In vivo anti-tumor effect of an anti-human PD-L1 antibody in the humanized PD-L1 mouse model. (Tecentriq is a monoclonal antibody specific for human PD-L1) (A)  PD-L1 humanized MC38 cells were subcutaneously implanted into humanized PD-L1 mouse model. Treatment of hPD-L1 antibody inhibited PD-L1 human .....
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Strain Information
  • Catalog Number ASHU-190039
  • Model Name PD-L1
  • Strain Name C57BL/6J - Cd274em2(hPD - L1)Asc
  • Mutation Type Humanized
  • GENE Synonyms B7h1, Pdl1, Pdcd1l1, Pdcd1lg1, A530045L16Rik
  • Human Orthologs CD274
  • Emsamble ID ENSMUSG00000016496
  • MGI ID 1926446
  • NCBI ID 60533
  • Backgound C57BL/6J
  • Coat Color Black
  • Mutation Type Humanized
Description

Validation Data

landingpage-ashu-190039-pl-l1 (2)-hu-icpmouse-1

 

Figure 1. The expression of human PD-L1 in the peripheral blood cells derived from homozygous humanized mice were confirmed by flow cytometry analysis. 

landingpage-ashu-190039-pd-l1 (2)-hu-icpmouse-2

landingpage-ashu-190039-pd-l1 (2)-hu-icpmouse-3

Figure 2.  In vivo anti-tumor effect of an anti-human PD-L1 antibody in the humanized PD-L1 mouse model. (Tecentriq is a monoclonal antibody specific for human PD-L1)

(A)  PD-L1 humanized MC38 cells were subcutaneously implanted into humanized PD-L1 mouse model. Treatment of hPD-L1 antibody inhibited PD-L1 humanized MC38 tumor growth, demonstrating that the humanized PD-L1 mice are a good in vivo model for validating the efficacy of antibodies targeting human PD-L1.

(B) Mean body weight of mice.  All quantitative data are represented as mean ± SEM.

Research Application
Immunotherapy, cancer research, drug screening
Availability
Mouse
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