PD-L1 (2)

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Strain Information

  • Catalog Number ASHU-190039
  • Model Name PD-L1
  • Strain Name C57BL/6J - Cd274em2(hPD - L1)/Asc
  • Mutation Type Humanized
  • GENE Synonyms B7h1, Pdl1, Pdcd1l1, Pdcd1lg1, A530045L16Rik
  • Human Orthologs CD274
  • Emsamble ID ENSMUSG00000016496
  • MGI ID 1926446
  • NCBI ID 60533
  • Background C57BL/6J
  • Coat Color Black
  • Mutation Type Humanized
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Validation Data

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Figure 1. The expression of human PD-L1 in the peripheral blood cells derived from homozygous humanized mice were confirmed by flow cytometry analysis. 


Figure 2. Immunotype in blood , spleen and bone marrow in hPD-L1 mice.  


Figure 3. Immunotype in blood in hPD-L1 mice. 


Figure 4. Immunotype in spleen in hPD-L1 mice. 


Figure 5. Immunotype in bone marrow in hPD-L1 mice. 

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Figure 6.  In vivo anti-tumor effect of an anti-human PD-L1 antibody in the humanized PD-L1 mouse model. (Tecentriq is a monoclonal antibody specific for human PD-L1)

(A)  PD-L1 humanized MC38 cells were subcutaneously implanted into humanized PD-L1 mouse model. Treatment of hPD-L1 antibody inhibited PD-L1 humanized MC38 tumor growth, demonstrating that the humanized PD-L1 mice are a good in vivo model for validating the efficacy of antibodies targeting human PD-L1.

(B) Mean body weight of mice.  All quantitative data are represented as mean ± SEM.

Immunotherapy, cancer research, drug screening