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Strain Information

  • Catalog Number ASHU-00102
  • Model Name PD-L1 & CTLA4
  • Strain Name C57BL/6-Ctla4em1(hCTLA4)Cd274em1(hPD - L1)/Asc
  • Mutation Type Humanized
  • GENE Synonyms Cd152, Ly-56, Ctla-4, B7h1, Pdl1, Pdcd1l1, Pdcd1lg1, A530045L16Rik
  • Human Orthologs CTLA4, CD274
  • Emsamble ID ENSMUSG00000026011, ENSMUSG00000016496
  • MGI ID 88556, 1926446
  • NCBI ID 12477, 60533
  • Background C57BL/6
  • Coat Color Black
  • Mutation Type Humanized
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Generation Strategy

Strategy for Generating Humanized PD-L1 (ASHU-00062) Mouse Model

landingpage-ashu-00102-PD-L1 & CTLA4-hu-icpmouse-1.1

Strategy for Generating Humanized CTLA4 (ASHU-00014) Mouse Model

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Validation Data

landingpage-ashu-00102-PD-L1 & CTLA4-hu-icpmouse-3

Figure 1. Splenocytes from homozygous hPD-L1/hCTLA4 mice were analyzed by flow cytometry after activation. The murine Pd-l1 (mPD-L1) and Ctla4 (mCTLA4) positive cells were detectable in wild type (WT) C57BL/6 mice, while the human (hPD-L1) and human (hCTLA4) positive cells were detectable in the homozygous hCTLA4/hPD-L1 mice. 

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landingpage-ashu-00102- PD-L1 & CTLA4-hu-icpmouse-4

Figure 2.  hCTLA-4/PD-L1 mice+ MC38 cells efficacy studies. We have developed a CTLA-4/PD-L1 dKI humanized model and tested the combined treatment of Yervoy and Tecentriq, and then observed improved efficacy in the combination treatment. 

Immunotherapy, cancer research, drug screening