PD-1 & SIRPA (2)

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Strain Information

  • Catalog Number ASHU-2000089
  • Model Name PD-1 & SIRPA
  • Strain Name C57BL/6 - Pdcd1em1(hPDCD1) Sirpaem1(hSIRPA)/Asc
  • Mutation Type Humanized
  • GENE Synonyms Ly101, Bit, P84, SIRP, SHP-1, CD172a, Ptpns1, SHPS-1, AI835480
  • Human Orthologs PDCD1, SIRPA
  • Emsamble ID ENSMUSG00000026285, ENSMUSG00000037902
  • MGI ID 104879, 108563
  • NCBI ID 18566, 19261
  • Background C57BL/6
  • Coat Color Black
  • Mutation Type Humanized
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  • Description
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This PD-1 and SIRPA double Knock-in strain is established by crossing PD-1-HU and SIRPA-HU mice together. These double double Knock-in mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Immunotherapy, drug screening