CD27 (2)

SKU :
ASHU-190035
Catalog # :
ASHU-190035
Availability :
Mouse

CD27 (2)

Humanized Strategy     Validation Data Figure 1. Detection of CD27 expression in peripheral blood cells of humanized CD27 mice. The expression of human CD27 was detected by FACS. The results showed that the active expression of human CD27 can be detected in both activated CD4+ and CD8+ T lymphocytes collected from humanized CD27 mice. Figure 2. Analysis of human CD27 expression in bone marrow by FACS . The homozygous KI mouse expresses human CD27 on CD4+ T cells. Figure 3. .....
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Strain Information
  • Catalog Number ASHU-190035
  • Model Name CD27 (2)
  • Strain Name C57BL/6 - Cd27tm3(hCD27)ASC
  • Mutation Type Humanized
  • GENE Synonyms S152, Tp55, Tnfrsf7
  • Human Orthologs CD27
  • Emsamble ID ENSMUSG00000030336
  • MGI ID 88326
  • NCBI ID 21940
  • Background C57BL/6
  • Coat Color Black
  • Mutation Type Humanized
Description

Humanized Strategy

landingpage-ashu-190035-cd27-hu-icpmouse-1

 

 

Validation Data

landingpage-ashu-190035-cd27-hu-icpmouse-2

Figure 1. Detection of CD27 expression in peripheral blood cells of humanized CD27 mice.

The expression of human CD27 was detected by FACS. The results showed that the active expression of human CD27 can be detected in both activated CD4+ and CD8+ T lymphocytes collected from humanized CD27 mice.

landingpage-ashu-190035-cd27-hu-icpmouse-3

landingpage-ashu-190035-cd27-hu-icpmouse-4

Figure 2. Analysis of human CD27 expression in bone marrow by FACS . The homozygous KI mouse expresses human CD27 on CD4+ T cells.

landingpage-ashu-190035-cd27-hu-icpmouse-5

landingpage-ashu-190035-cd27-hu-icpmouse-6

Figure 3. Analysis of human CD27 expression in the spleen by FACS . The homozygous KI mouse expresses human CD27 on CD4+ T cells.

Research Application
Immunotherapy, cancer research, drug screening
Availability
Mouse
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