CD38 (2)

SKU :
ASHU-190059
Catalog # :
ASHU-190059
Availability :
Mouse

CD38 (2)

Humanized Strategy Validation Data Figure 1. Detection of CD38 expression in live cells from PBMC of humanized CD38 mice. The FACS results showed that the high expression of humanized CD38 was detected in B, T, NK cells from PBMC of Homozygous humanized CD38 mice. Figure 2. Detection of CD38 expression in live cells from the spleen of humanized CD38 mice. The FACS results showed that the high expression of humanized CD38 was detected in B, T, NK cells from the spleen of Homozygous hum .....
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Strain Information
  • Catalog Number ASHU-190059
  • Model Name CD38
  • Strain Name C57BL/6 - Cd38em2(CD38)Asc
  • Mutation Type Humanized
  • GENE Synonyms I-19, ADPRC 1, Cd38-rs1
  • Human Orthologs CD38
  • Emsamble ID ENSMUSG00000029084
  • MGI ID 107474
  • NCBI ID 12494
  • Background C57BL/6
  • Coat Color Black
  • Mutation Type Humanized
Description

Humanized Strategy

Landingpage-ASHU-190059-CD38-HU-ICPMouse-1

Validation Data

Landingpage-ASHU-190059-CD38-HU-ICPMouse-2

Figure 1. Detection of CD38 expression in live cells from PBMC of humanized CD38 mice.

The FACS results showed that the high expression of humanized CD38 was detected in B, T, NK cells from PBMC of Homozygous humanized CD38 mice.

Landingpage-ASHU-190059-CD38-HU-ICPMouse-3

Figure 2. Detection of CD38 expression in live cells from the spleen of humanized CD38 mice.

The FACS results showed that the high expression of humanized CD38 was detected in B, T, NK cells from the spleen of Homozygous humanized CD38 mice.

lamdingpage-ashu-190059-cd28(2)-hu-icpmouse-4

landingpage-ashu-190059-cd38(2)-hu-icpmouse-5

Figure 3. In vivo anti-tumor effect of Daratumumab, a humanized anti-CD38 antibody, in a humanized mouse model of CD38

Homozygous humanized CD38 mice were inoculated with E.G7-­OVA T lymphoma cells. The results showed: Daratumumab, a drug targeting human CD38, showed a very significant anti-tumor effect, demonstrating that the humanized CD38 mouse model is a good in vivo model for validating the efficacy of antibodies targeting human CD38.( Data in partnership with collaborators )

Research Application
Immunotherapy, cancer research, drug screening
Availability
Mouse
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