Humanized Strategy
Validation Data
Figure 1. Detection of CD38 expression in live cells from PBMC of humanized CD38 mice.
The FACS results showed that the high expression of humanized CD38 was detected in B, T, NK cells from PBMC of Homozygous humanized CD38 mice.
Figure 2. Detection of CD38 expression in live cells from the spleen of humanized CD38 mice.
The FACS results showed that the high expression of humanized CD38 was detected in B, T, NK cells from the spleen of Homozygous humanized CD38 mice.
Figure 3. In vivo anti-tumor effect of Daratumumab, a humanized anti-CD38 antibody, in a humanized mouse model of CD38
Homozygous humanized CD38 mice were inoculated with E.G7-OVA T lymphoma cells. The results showed: Daratumumab, a drug targeting human CD38, showed a very significant anti-tumor effect, demonstrating that the humanized CD38 mouse model is a good in vivo model for validating the efficacy of antibodies targeting human CD38.（ Data in partnership with collaborators ）