CD20 (2)

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Strain Information

  • Catalog Number ASHU-200114
  • Model Name CD20 (2)
  • Strain Name C57BL/6-Ms4a1tm2 (hCD20)/Asc
  • Mutation Type Humanized
  • GENE Synonyms cd20, Ly-44, Ms4a1, AA960661
  • Human Orthologs CD20
  • Emsamble ID ENSMUSG00000024673
  • MGI ID 88321
  • NCBI ID 12482
  • Background C57BL/6
  • Coat Color Black
  • Mutation Type Humanized
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Validation Data

landingpage-ashu-200114-cd20 (2)-hu-icpmouse-1

Figure1. Human CD20 expression on B cells is confirmed by FACS analysis in the heterozygous humanized CD20 mice. The heterozygous KI animal expresses both human and murine CD20 on CD19+ B cells.

landingpage-ashu-200114-cd20 (2)-hu-icpmouse-2

Figure 2. Human CD20 expression on CD45+ cells is confirmed by FACS analysis in WT, heterozygous, and homozygous humanized CD20 mice. The WT animal expresses mouse CD20 on CD45+ cells, and the homozygous KI expresses human CD20, while the heterozygous KI expresses both human and murine CD20.

Immune-related, drug screening