Validation Data
Figure1. Human CD20 expression on B cells is confirmed by FACS analysis in the heterozygous humanized CD20 mice. The heterozygous KI animal expresses both human and murine CD20 on CD19+ B cells.
Figure 2. Human CD20 expression on CD45+ cells is confirmed by FACS analysis in WT, heterozygous, and homozygous humanized CD20 mice. The WT animal expresses mouse CD20 on CD45+ cells, and the homozygous KI expresses human CD20, while the heterozygous KI expresses both human and murine CD20.