- Catalog Number ASC-5900
Cancer immunotherapy is a type of treatment for cancer that uses the patient’s own immune system to fight cancer by improving or modulating the immune system to attack cancer cells. Immunotherapy has been very successful in improving cancer survival rate in recent years either as a standalone treatment option or in combination with other types of cancer treatment.
One type of immunotherapy called Immune Checkpoint therapy targets immunoregulatory proteins called immune checkpoints (ICPs) that exert negative or positive control on T cell activity and are dysregulated in cancer to help cancer cells evade the immune system. To enable T cells to recognize cancer cells and eliminate them, monoclonal antibodies are used to block specific negative immune checkpoint proteins and have proven to be very effective in treating many different types of cancer. More recently novel immunotherapies that stimulate positive immune checkpoint proteins in order to boost T cell response and clearance of cancer cells are in development.
With the ever-increasing number of immunotherapy drugs in the pipeline, there is a critical need for predictive in vivo models that can mimic the tumor microenvironment in patients for the assessment of novel cancer immunotherapy agents and provide better translational results. Mouse models have been the most frequently used and widely accepted in vivo model for evaluating drug efficacy. But there is only a 60% homology between human and murine immune genes and antibodies that recognize human .
Applied StemCell offers "best-in-class" custom services to evaluate the efficacy/ pharmacodynamics of your investigational antibody candidates in our functionally validated oncology mouse models:
Screen your early-stage lead antibodies using our antibody efficacy testing platform and make informed go-no-go decisions before more expensive GLP testing:
We also offer antibody testing for other immune related disorders such as autoimmune diseases.
* Endpoint: Tumor burden should not exceed 10% of the animal’s bodyweight. The study will be terminated with euthanizing all animals when the mean tumor volume reaches about 3000 mm^3.
Optional post-mortem tests include: Blood RT/Biochemical analysis; FACS analysis on PBMC (including CBA); serum/ plasma preparation and then ELISA, MSD or WB analysis, qPCR,WB, IHC, IF, TILs analysis
Timeline: 2-3 months after receipt of antibodies