IL6 - Immune Checkpoint Mouse Models - Mouse Repository - Animal Models - Research

SKU :
ASHU-18017
Catalog # :
ASHU-18017
Availability :
Mouse
IL6 Humanized Strategy Humanized IL6 Mice Responded to LPS Stimulation and Robustly Expressed Human IL6 Validation of human IL6 mRNA and protein expression by Realtime-PCR and ELISA Mice were divided into two groups. One group was intraperitoneally injected with LPS at 3 mg/kg body weight, and the other group was injected with normal saline. After 4 h stimulation, the livers were harvested to extract RNA and the serum were used to detect protein expression. (HO: humanized IL6 homozygous .....
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Strain Information
  • Catalog Number ASHU-18017
  • Model Name IL6
  • Strain Name C57BL/6 - Il6 tm1(hIL6)ASC
  • Mutation Type Humanized
  • GENE Synonyms Il-6
  • Human Orthologs IL6
  • Emsamble ID ENSMUSG00000025746
  • MGI ID 96559
  • NCBI ID 16193
  • Backgound C57BL/6J
  • Coat Color Black
  • Mutation Type Humanized
Description

IL6 Humanized Strategy

Landingpage-ASHU-18017-IL6-HU-ICPMouse-1

Humanized IL6 Mice Responded to LPS Stimulation and Robustly Expressed Human IL6

Landingpage-ASHU-18017-IL6-HU-ICPMouse-2

Validation of human IL6 mRNA and protein expression by Realtime-PCR and ELISA

Mice were divided into two groups. One group was intraperitoneally injected with LPS at 3 mg/kg body weight, and the other group was injected with normal saline. After 4 h stimulation, the livers were harvested to extract RNA and the serum were used to detect protein expression. (HO: humanized IL6 homozygous mice; WT: wild type C57BL/6 mice)

Research Application
Immunotherapy
Availability
Mouse
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